Roscovitine
- Catalog NO.:A813074
- CAS No. : 186692-46-6
- Molecular Formula:C19H26N6O
- Molecular Weight: 354.45
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Product Details
CAS Number | 186692-46-6 | Appearance | Off-white to light yellow powder |
Catalog Number | A813074 | MDL Number | MFCD02266401 |
Molecular Formula | C19H26N6O | Molecular Weight | 354.45 |
Boiling Point | Melting Point | ||
Flash Point | Density | ||
Synonyms | (2R)-2-[[6-(benzylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-ol | ||
Storage Condition | Store in a tightly closed container,in a cool and dry place |
Safety
GHS Pictogram | |||
Signal Word | Warning | UN Number | |
Hazard Statements | H303+H313+H333-H315-H319-H335 | Class | |
Precautionary Statements | P261-P280-P301+P312-P305+P351+P338 | Packing Group |
Description
Seliciclib, also known as roscovitine and CYC202, is a n orally bioavailable, small-molecule cyclin-dependent kinase (CDK) inhibitor with potential proapoptotic and antineoplastic activities. Seliciclib primarily inhibits CDK2/E, CDK2/A, CDK7 and CDK9 by competing for their ATP binding sites, leading to a disruption of cell cycle progression. In addition, this agent appears to interfere with CDK-mediated phosphorylation of the carboxy-terminal domain of RNA polymerase II, inhibiting RNA polymerase II-dependent transcription, which may result in the down-regulation of antiapoptotic proteins such as induced myeloid leukemia cell differentiation protein Mcl-1. |